Hydrochlorothiazide More Drug_uses Hydrochlorothiazide And Furosemide. Which Is More Likely To Cause An Acid/base Imbalance And Why?

Hydrochlorothiazide and furosemide. Which is more likely to cause an acid/base imbalance and why? - hydrochlorothiazide more drug_uses

To answer the first question I would like to define what is a diuretic. It is a drug that increases the excretion of sodium. Sodium Wherever he goes, water follows.
Both thiazides (Hydrocholorthiazide) and loop diuretics (furosemide)) is a metabolic alkalosis (with hypokalemia - a greater loss of potassium. Loop diuretics in the ascending loop of Henle work (where 25% of the salt absorption occurs), whereas thiazide diuretics work in the distal convoluted tubule (including 10% of the absorption of salt). While loop diuretics are more and more as thiazides.
If you block the reabsorption of sodium, takes the body back dived in nephrons in the medulla. This is done by the end of the distal convoluted tubule in the area above the manifold. A potassium + / heat exchanger that pumps sodium and potassium acidic hydrogen in the light of the nephron sodium excretion during the injection back into the body. Diuretics do not work here.
Not now, I'm 100% sure, but think logically is what &# 039; m pretty sure that this happens. This means that the left of sodium in the tube by the action of a diuretic, the more potassium and hydrogen will be replaced by the last bomb. And as the loop diuretics are more powerful than thiazide diuretics, which carries more sodium in the lumen of the nephron varied to allow greater exchange of potassium-sodium + acid in the segment on. Because hydrogen is lost, leading to metabolic alkalosis. While loop diuretics, it would be likely to cause metabolic acidosis and hypokalemia. I do not know if this is true in practice, but logically, that what I think is should be done.